A facile one-pot four-component synthesis of dihydropyrrol-2-ones using Cl3CCO2H
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Abstract:
A convenient synthesis of different types of polyfunctional dihydropyrrol-2-ones via one-pot four component reactions of formaldehyde, dialkyl acetylenedicarboxylates and amines, catalyzed by trichloroacetic acid (Cl3CCO2H) at room temperature has been investigated. The significant advantages of this synthetic method are mild reaction conditions, available and inexpensive material, short reaction times, good yields, simple work-up.
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Journal title
volume 5 issue 1
pages 9- 14
publication date 2015-03-01
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